Sulbactam Acid
Sulbactam Acid: A Comprehensive Guide
Sulbactam Acid is a beta-lactamase inhibitor widely used in combination with antibiotics to enhance their effectiveness against resistant bacterial strains. This white crystalline powder is a crucial component in modern antibacterial therapies, particularly in hospital settings.
Product Specifications
- Chemical Name: (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
- Molecular Formula: C8H11NO5S
- Molecular Weight: 233.24 g/mol
- Appearance: White to off-white crystalline powder
- Purity: ≥98% by HPLC
- Solubility: Soluble in water (50 mg/mL)
- Storage: 2-8°C in airtight container
- Shelf Life: 24 months when properly stored
Detailed Specifications Table
| Parameter | Specification | Test Method |
|---|---|---|
| Assay | 98.0-102.0% | HPLC |
| Water Content | ≤1.0% | Karl Fischer |
| Residue on Ignition | ≤0.2% | USP |
| Heavy Metals | ≤20 ppm | ICP-MS |
| Related Substances | ≤2.0% total | HPLC |
| Bacterial Endotoxins | ≤0.17 EU/mg | LAL |
| Sterility | Sterile | USP |
Applications of Sulbactam Acid
Sulbactam Acid is primarily used in combination with beta-lactam antibiotics to overcome bacterial resistance mechanisms. Common applications include:
- Combination therapy with ampicillin (as sulbactam sodium)
- Treatment of intra-abdominal infections
- Skin and soft tissue infections
- Gynecological infections
- Respiratory tract infections
Sulbactam Acid FAQ
1. What is the mechanism of action of Sulbactam Acid?
Sulbactam Acid works by irreversibly inhibiting beta-lactamase enzymes produced by bacteria. These enzymes normally break down beta-lactam antibiotics, rendering them ineffective. By inhibiting these enzymes, Sulbactam Acid allows the accompanying antibiotic to maintain its antibacterial activity against resistant strains.
2. What are the storage requirements for Sulbactam Acid?
Sulbactam Acid should be stored at controlled room temperature (15-30°C) or refrigerated (2-8°C) in airtight containers protected from light and moisture. For long-term storage exceeding 6 months, refrigeration is recommended to maintain optimal stability.
3. Can Sulbactam Acid be used alone as an antibiotic?
No, Sulbactam Acid has weak antibacterial activity on its own. It must be combined with appropriate beta-lactam antibiotics to provide therapeutic benefit. The antibacterial spectrum and effectiveness depend on the specific antibiotic it's paired with, typically ampicillin or cefoperazone.
Safety Information
When handling Sulbactam Acid, observe standard laboratory safety precautions:
- Wear appropriate personal protective equipment (lab coat, gloves, eye protection)
- Avoid inhalation of dust
- Prevent contact with skin and eyes
- Use in well-ventilated areas
- Follow proper disposal procedures for pharmaceutical waste
Quality Assurance
Our Sulbactam Acid undergoes rigorous quality control testing to ensure compliance with international pharmacopeia standards (USP, EP, JP). Each batch is accompanied by a Certificate of Analysis including:
- Identity confirmation (FTIR, HPLC)
- Purity assessment
- Impurity profile
- Residual solvent analysis
- Microbiological testing
Shipping Information
| Package Size | Shipping Method | Estimated Delivery |
|---|---|---|
| 1-5 g | Express Courier | 3-5 business days |
| 10-100 g | Air Freight | 5-7 business days |
| 1 kg+ | Sea Freight | 15-30 business days |
Sulbactam Acid in Pharmaceutical Formulations
In pharmaceutical products, Sulbactam Acid is typically converted to its sodium salt (sulbactam sodium) for better solubility. Common formulations include:
- Powder for injection (with ampicillin or other antibiotics)
- Ready-to-use solutions (in specific markets)
- Fixed-dose combinations
Additional FAQ
4. What is the typical dosage of Sulbactam Acid in combination therapies?
The dosage varies depending on the infection being treated and the antibiotic it's paired with. For ampicillin-sulbactam combinations, the typical adult dose ranges from 1.5-3 g every 6 hours (containing 0.5-1 g Sulbactam Acid component). Pediatric dosing is based on body weight.
5. Are there any known drug interactions with Sulbactam Acid?
Sulbactam Acid may interact with probenecid, which can decrease its renal excretion and increase blood levels. When combined with aminoglycosides, physical incompatibility may occur if mixed in the same IV solution. Always consult prescribing information for specific combination products.
6. What stability data is available for Sulbactam Acid solutions?
Reconstituted solutions of Sulbactam Acid (as sulbactam sodium) are typically stable for 24 hours at room temperature and 72 hours when refrigerated. For IV infusion solutions, stability depends on the diluent used and the concentration. Always follow manufacturer recommendations for specific products.
Technical Support
Our technical team provides comprehensive support for Sulbactam Acid including:
- Formulation assistance
- Stability studies
- Analytical method development
- Regulatory documentation
- Troubleshooting guidance
For bulk inquiries or custom formulations containing Sulbactam Acid, please contact our sales team with your specific requirements.