tert-Butyldimethylchlorosilane
High-Quality tert-Butyldimethylchlorosilane for Industrial Applications
tert-Butyldimethylchlorosilane is a highly versatile organosilane compound widely used in pharmaceutical synthesis, organic chemistry, and material science. This premium-grade chemical offers excellent stability and reactivity, making it ideal for various protection and derivatization reactions.
Product Specifications
- Chemical Name: tert-Butyldimethylchlorosilane
- CAS Number: 18162-48-6
- Molecular Formula: C6H15ClSi
- Molecular Weight: 150.72 g/mol
- Appearance: Colorless to pale yellow liquid
- Purity: ≥98% (GC)
- Boiling Point: 142-144°C
- Density: 0.86 g/cm³ at 25°C
- Flash Point: 28°C
- Storage Conditions: Store under inert gas at 2-8°C
Technical Specifications
| Parameter | Specification |
|---|---|
| Assay (GC) | ≥98% |
| Water Content | ≤0.1% |
| Chloride Content | ≤0.5% |
| Residual Solvents | ≤0.5% |
| Heavy Metals | ≤10 ppm |
| Packaging | 50g, 100g, 500g, 1kg, 5kg, 25kg |
Key Applications
- Protecting group for alcohols in organic synthesis
- Intermediate for silicon-containing pharmaceuticals
- Surface modification of silica materials
- Preparation of silicon rubber additives
- Derivatization reagent in analytical chemistry
Safety Information
| Hazard Statements | Precautionary Measures |
|---|---|
| H314 - Causes severe skin burns and eye damage | P280 - Wear protective gloves/protective clothing/eye protection/face protection |
| H290 - May be corrosive to metals | P234 - Keep only in original packaging |
| H225 - Highly flammable liquid and vapor | P210 - Keep away from heat/sparks/open flames/hot surfaces |
tert-Butyldimethylchlorosilane FAQ
What is the primary use of tert-Butyldimethylchlorosilane in organic synthesis?
tert-Butyldimethylchlorosilane is primarily used as a protecting group for hydroxyl groups in organic synthesis. It reacts with alcohols to form tert-butyldimethylsilyl (TBS) ethers, which are stable under various reaction conditions but can be selectively removed when needed. This property makes it particularly valuable in multi-step synthetic sequences.
How should tert-Butyldimethylchlorosilane be stored to maintain its quality?
tert-Butyldimethylchlorosilane should be stored under inert gas (nitrogen or argon) at temperatures between 2-8°C in tightly sealed containers. It's moisture-sensitive and reacts violently with water, so proper desiccation is essential. The containers should be kept in a cool, well-ventilated area away from direct sunlight and heat sources.
What safety precautions are necessary when handling tert-Butyldimethylchlorosilane?
When handling tert-Butyldimethylchlorosilane, always work in a fume hood with proper personal protective equipment including chemical-resistant gloves, safety goggles, and lab coat. Avoid contact with skin and eyes, and never allow it to come in contact with water. In case of spills, neutralize with appropriate absorbents under inert atmosphere and dispose according to local regulations.
Handling and Storage Recommendations
- Always handle under inert atmosphere (N2 or Ar)
- Use anhydrous solvents and moisture-free glassware
- Keep away from oxidizing agents and strong bases
- Use flame-proof equipment when working with large quantities
- Transfer using syringe techniques for small quantities
Quality Assurance
Our tert-Butyldimethylchlorosilane undergoes rigorous quality control including:
- GC purity testing
- Moisture content analysis
- FTIR spectroscopy verification
- NMR confirmation
- Heavy metal screening
Shipping Information
| Shipping Class | Packaging | Regulatory Information |
|---|---|---|
| Hazard Class 8 | Amber glass bottles with PTFE-lined caps | UN2924, PG II |
| Corrosive Liquid | Sealed metal cans for larger quantities | Proper Shipping Name: Corrosive liquid, flammable, n.o.s. |