Acetyl chloride
Acetyl Chloride: High-Quality Chemical Compound for Industrial Applications
Acetyl chloride (CH3COCl) is a vital chemical reagent widely used in organic synthesis and industrial processes. This colorless, corrosive liquid with a pungent odor serves as an important acetylating agent in pharmaceutical, agrochemical, and dye manufacturing industries.
Product Specifications
- Chemical Formula: CH3COCl
- Molecular Weight: 78.49 g/mol
- Appearance: Colorless to light yellow liquid
- Odor: Pungent, irritating
- Boiling Point: 51-52°C (124-126°F)
- Melting Point: -112°C (-170°F)
- Density: 1.104 g/mL at 25°C
- Purity: ≥99%
Technical Data
| Parameter | Specification |
|---|---|
| Assay (GC) | ≥99.0% |
| Water Content | ≤0.1% |
| Iron (Fe) Content | ≤5 ppm |
| Chloride Content | ≤0.01% |
| Residue on Evaporation | ≤0.01% |
Storage and Handling
Acetyl chloride should be stored in tightly sealed containers under inert atmosphere at temperatures not exceeding 30°C. Keep away from moisture, heat, and incompatible materials such as water, alcohols, and strong oxidizers. Use appropriate personal protective equipment (PPE) including chemical-resistant gloves, goggles, and fume hood when handling.
Acetyl Chloride FAQ
Q: What are the main industrial applications of acetyl chloride?
A: Acetyl chloride is primarily used as an acetylating agent in organic synthesis. Its major applications include pharmaceutical manufacturing (production of aspirin and other drugs), agrochemical production, dye synthesis, and as a reagent in Friedel-Crafts acylation reactions. It's also used in the production of acetic anhydride and other acetyl derivatives.
Q: Why is acetyl chloride considered hazardous?
A: Acetyl chloride is highly reactive with water and moisture, producing corrosive hydrogen chloride gas and acetic acid. It's flammable (flash point 4°C) and its vapors can form explosive mixtures with air. The substance is corrosive to skin, eyes, and respiratory tract, requiring careful handling under proper ventilation with appropriate protective equipment.
Packaging Options
| Package Size | Container Type | Gross Weight |
|---|---|---|
| 100 ml | Glass bottle | 250 g |
| 500 ml | Glass bottle | 1.2 kg |
| 1 kg | Steel drum | 1.5 kg |
| 25 kg | Plastic drum | 28 kg |
Safety Information
- Hazard Statements: H225, H314, H335
- Precautionary Measures: P210, P233, P240, P241, P242, P243, P260, P261, P264, P271, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P363, P370+P378, P403+P233, P403+P235, P405, P501
- UN Number: UN1717
- ADR/RID Class: 3/8
- ADR/RID Hazard Number: 38
- Packing Group: II
Acetyl Chloride FAQ
Q: Can acetyl chloride be shipped internationally?
A: Yes, acetyl chloride can be shipped internationally but with strict regulations. It's classified as a hazardous material (UN 1717) under Class 3 (Flammable liquid) and Class 8 (Corrosive substance). Shipping requires proper dangerous goods documentation, certified packaging, and trained personnel. Many carriers have special requirements or restrictions for transporting acetyl chloride, so it's essential to consult with experienced chemical logistics providers.
Quality Assurance
Our acetyl chloride undergoes rigorous quality control testing to ensure it meets the highest industry standards. Each batch is accompanied by a Certificate of Analysis (CoA) detailing purity levels and impurity profiles. We maintain strict quality control from raw material sourcing through production and packaging to deliver consistent, high-performance acetyl chloride for industrial applications.
Applications in Detail
In pharmaceutical synthesis, acetyl chloride serves as a key reagent for introducing acetyl groups into organic molecules. It's particularly valuable in the preparation of active pharmaceutical ingredients (APIs) where specific acetylation reactions are required. In the dye industry, it's used to manufacture various azo dyes and pigment intermediates. The compound also finds use in analytical chemistry as a derivatization agent for gas chromatography analysis of alcohols and phenols.
Environmental Considerations
Due to its reactivity with water and potential to release hydrogen chloride gas, acetyl chloride requires careful environmental management. Spills must be contained immediately using inert absorbents, never with water. Waste disposal should be performed by licensed hazardous waste handlers following local regulations. When properly controlled in industrial settings, acetyl chloride can be used safely with minimal environmental impact.
Acetyl Chloride FAQ
Q: What are the alternatives to acetyl chloride for acetylation reactions?
A: While acetyl chloride is highly effective, alternatives include acetic anhydride (less reactive but more stable), acetyl bromide (more reactive but more expensive), and ketene (gas requiring special equipment). Each alternative has different reactivity, cost, and safety profiles that must be considered for specific applications. In some cases, enzymatic acetylation methods may be viable for sensitive compounds, though these typically have higher costs and lower reaction rates.
Custom Solutions
We offer custom packaging and purity options for acetyl chloride to meet specific customer requirements. Technical support is available to help optimize your processes using acetyl chloride, including recommendations for handling, storage, and waste management. Our team can provide specialized formulations or modified purity grades for unique industrial applications.